Conaghan P et al. Is progressive osteoarthritis an atheromatous vascular disease? Ann Rheum Dis. 2005;64:1539-41.
The answer to the title of this article is es.鈥?For all practical purposes, the chemistry of osteoarthritis and atherosclerotic heart disease is identical. The view we should take is as follows: osteoarthritis is 鈥渉eart disease鈥?of the joints and heart disease is 鈥渙steoarthritis鈥?of arteries.
The difficulty that most have when considering this fact is that, to the naked eye, joints and arteries are very different structures. While that is true, it should not detract one from focusing on the chemistry of each condition Nike Air Force 1 Low Mens Clearance , which is a shared state of chronic inflammation that is essentially identical.
It is generally known by many people that type 2 diabetes is a risk factor for heart disease. The reason for this is that diabetes is an inflammatory state, which predisposes one to develop related inflammatory diseases, such as heart disease. It is not well known, but equally factual, that people with diabetes are also more likely to develop osteoarthritis (1).
This relationship between diabetes and OA is obvious and becoming more well known Cheap Nike Air Force 1 Low , yet it is still difficult for many to conceptualize that OA is heart disease of joints. The fact that must be embraced is that if the inflammatory state of diabetes promotes both heart disease and OA, it means that they have similar causes and similar pro-inflammatory chemistry changes.
As stated earlier, osteoarthritis is misperceived to be a 鈥渨ear-and-tear鈥?condition that is mostly caused by direct joint injury. Superficially this appears true and is most obvious in athletes with knee injuries. What is lost in this superficial perception is that most people also develop aches and pains in joints that they did NOT injure. So in this case, an ex-running back may have painful OA of the knee due to injury, but also has pain in other joints that were never injured.
The reason OA expresses in non-injured joints as we age involves a 鈥渨ear and lack of repair鈥?state and has nothing to do with wear-and-tear of joint tissues. How do we know this for sure? Because Nike Air Force 1 Low Clearance , in the research setting it was determined that before joints develop OA, their fatty acid profile changes from one that is anti-inflammatory and healing to one that is pro-inflammatory and thus, non-healing and non-repairing (2,3). The outcome is a joint that does not heal over time as a consequence of normal 鈥渨ear鈥?and can slowly take on the appearance of being 鈥渢orn鈥?when the joint becomes painful and subsequently viewed at surgery or with radiological imaging (4).
Basic nutritional factors that have been implicated in the expression of osteoarthritis over time include omega-6 fatty acids (2), a lack of vitamin D (5) Cheap Nike Air Force 1 High Mens , and a lack of magnesium (6). All of these and more nutritional factors that create chronic inflammation are outlined in The DeFlame Diet. In other words, if you read and understand The DeFlame Diet, you will understand how osteoarthritis, heart disease, and other chronic diseases develop as we age.
Source: Total Views: 23Word Count: 598See All articles From Author If you are self-employed Nike Air Force 1 High Mens Clearance , work on a contract basis, or have an income that is irregular or comes from multiple sources, it will generally be harder for you to get a mortgage than it is for someone who is an employee and can easily prove their income.
A self-employed person is someone who runs their own business and works for themselves without an employer. Directors of small limited companies, although technically employed on a PAYE basis, will generally be classed as self employed when it comes to applying for a mortgage or remortgage.
With over three million self-employed individuals in the UK Cheap Nike Air Force 1 High Womens , the attitude of many mortgage lenders towards the self-employed population is a problem that can affect a large number of people, even though many self-employed people often earn more than a lot of salaried workers.
The problem stems from the fact that the majority of mainstream mortgage lenders require proof of income when assessing a mortgage or remortgage application. Employed people can use their payslips and P60 as proof of salary, but there is no such straightforward equivalent if you are self-employed.
In place of payslips, self-employed workers may be asked to provide audited accounts that show their income over the last three years. However, in many cases Nike Air Force 1 High Womens Clearance , these accounts will not give an accurate reflection of how much money a self-employed person is making. This is because if the accountant who prepared the accounts is doing his job properly, he will have offset as many allowable expenses as possible against tax. This has the effect of reducing the self-employed person's net profit, upon which the lender will base the size of mortgage or remortgage they are prepared to offer.
The situation is even worse for the newly self-employed, as they may not yet have been trading long enough to have had three years' worth of accounts prepared.