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CHICAGO Emmitt Smith Youth Jersey , Nov. 28 (Xinhua) -- Researchers at the University of Illinois (UI) are trying to use tiny drug-laden nanoparticles to seek and destroy cancer stem cells.


They used the nanoparticles to deliver niclosamide that targets a protein called CD44 only appearing on the surface of cancer stem cells, and found the cancer stem cells lost their stemlike properties after treatment with the niclosamide-bearing targeted nanoparticles, and are less able to cause the cancer to recur or metastasize.


The researchers also detected a significant decrease in overall cancer cell growth Xavier Woods Youth Jersey , both in the cell cultures and in the mice, according to a report released Monday on the UI website.


"I call them 'GPS-enabled nanoparticles,' because they seek out only the cells that have cancer stem cell properties. Then they latch onto the cells and deliver the drug Jourdan Lewis Youth Jersey ," said Dipanjan Pan, a UI professor of bioengineering. "To the best of our knowledge, this is the first demonstration of delivering cancer stem-cell-targeted therapy with a nanoparticle."


Cancer stem cells represent a tiny fraction of cells in a tumor Mike White Youth Jersey , but it only takes one or two to seed a new tumor, Pan said. The challenge for physicians and researchers is not only finding these cells, but treating them.


Previous study found that niclosamide works on a particular gene-regulation pathway in cancer stem cells. Niclosamide is on the World Health Organization's List of Essential Medicines Dalton Schultz Youth Jersey , which is an index of the safest and most effective drugs in the world, and is a drug commonly prescribed to treat tapeworm infections.


"This work is important to future researchers working in the field of cancer stem cells," said postdoctoral researcher Santosh Misra Dorance Armstrong Jr. Youth Jersey , the first author of the study. "We described and confirmed the proteins and genes responsible for vital processes in these cells, and that is opening up new avenues to make better therapies."


UI researchers are now working to create a combination therapy that can deliver drugs for the primary cancer, such as traditional chemotherapies Michael Gallup Youth Jersey , as well as targeted agents that can treat cancer stem cells. They are also testing the nanoparticle drug-delivery system in large animal models to bring it a step closer to the clinic.


The study has been published in the journal Molecular Cancer Therapeutics.






by Maria Watson Pelaez


LISBON， April 23 (Xinhua) -- MEO Fan event 2016 kicked off here on Saturday， offering both adults and children the chance to explore and play， building with Lego blocks， playing video games among a variety of activities.


"This is the second edition of this toy fair where we have several collections， with the highlight this year being the Titanic ship made of 220，000 pieces，" curator of the event Paulo Neves told Xinhua.


The ship was made by Bright Bricks， led by Ed Diment， and took at least three months to make.


Neves also pointed to the giant Lego constructions of footballers Cristiano Ronaldo and Eusebio in the entrance， Portugal's main football stars.


Neves had his own lighthouse made out of Lego blocks on display which he purchased recently.


The "Megabloks" area was undoubtedly most popular among children， where they built their dream homes and animals.


"My 6 year old daughter loved the pool of (Lego) pieces，" said Sonia Realista， 39， an architect. "I am always wanting her to play Lego but she wasn't very interested at home， so I think this event is really important for children to play and use their heads."


Her daughter made a house out of Lego blocks， but Realista had enjoyed seeing the Lego constructions made by professionals， where you could see on display an impressive number of miniature detailed villages， with shops， a cinema， trees， and people， and the streets lined with trees， as well as a train track.


At the other end of the event there is a Barbie section where you can find collections styled by Raul Lopes， who purchases the barbies and then designs their clothes and scene.


His collections on display included "Florence and the Machine，" "Costume Ball" and "Lusitana Paixao." In another collection he had portrayed a Portuguese pop band from the 1980s called Doce， composed of four women.


Children had their pictures taken in another corner which their parents could later find on Facebook， with the girls sitting in a princess-like chair.